Screening Capabilities with AbTheneum

SimulScreen Assays
Screen antibodies for affinity, cross-reactivity, specificity, and blocking activity. Combine several SimulScreen assays for truly dynamic data.

SurfScreen Assays
New assay capabilities introduced at AET 2020 this year includes screening for cell-binding activity for membrane targets. Coming soon is a customized functional assay to find rare functional hits in the discovery process.

Sequencing & Informatics
As always with AbTheneum, never throw away any data. AbTheneum sequences all the antibodies simultaneously and pairs the assay data from SimulScreen and SurfScreen with the native full-length sequences.

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AbTheneum Lead Selection - TIGIT Case Study

In this case study, we demonstrate how we filter 456 anti-TIGIT antibodies down to 5 functional leads by maximizing sequence diversity across several sequence families. This demonstrates the powerful output from AbTheneum and the importance of early functional testing. Using this workflow, SCT took 3 months to take lymphocytes from immunized animals to functional leads.

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AbTheneum Lead Selection - TIM3 Case Study

We discovered 195 unique sequences of antibodies that bind to TIM3. In this case study, we selected the most diverse set of antibodies across several related families for reconstruction. In a cell-based functional bioassay, 3 SCT antibodies perform as well as clinical candidates. Using this workflow, SCT took 3 months to take lymphocytes from immunized animals to functional leads.

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